Dr Giulia Bastianello | Mechanical Properties of Materials | Best Researcher Award

Dr. Giulia Bastianello is an accomplished molecular oncology researcher specializing in DNA damage response and mechanobiology 🧬. She earned her Ph.D. from IFOM, Milan (2017) 🎓, following a Master’s in Molecular Biology (2012) and a Bachelor’s in Biology (2010) from the University of Milan. Currently a Research Fellow at IFOM 🔍, she explores how mechanical stress impacts genome stability, with a focus on the ATM kinase pathway. Recognized with the NAF2020 Young Investigator Award 🏆, she has published in Nature Communications, Cell Reports, and PNAS 📖. Her pioneering work advances cancer research and cellular resilience 🔬.

Dr Giulia Bastianello, IFOM-ETS, Italy

Profile

ORCID

Education 🎓

Dr. Giulia Bastianello holds a Ph.D. in Molecular Oncology from IFOM (the FIRC Institute of Molecular Oncology) in Milan, Italy (2017), where she conducted groundbreaking research under the supervision of Prof. Marco Foiani. Prior to that, she completed her Master’s degree in Molecular Biology (2012) and her Bachelor’s degree in Biology (2010), both from the University of Milan, achieving summa cum laude honors. Her academic journey has been marked by a deep commitment to understanding cellular mechanisms and DNA damage responses.

Experience 🔬

Dr. Bastianello has been a Research Fellow at IFOM since 2017, where she investigates the intricate relationship between DNA damage response and mechanical stress, focusing on the ATM kinase. Her research experience also includes roles as a doctoral student at IFOM and multiple thesis projects related to gene recombination and replication stress responses. Through these roles, she has honed her expertise in molecular biology, cell mechanics, and cancer biology.

Research Focus 🧬

Dr. Bastianello’s research explores the intersection of mechanobiology and genomic stability. She focuses on how mechanical stress influences the DNA damage response, with particular attention to the ATM kinase pathway. Her work has critical implications for understanding cancer progression, cellular resilience, and potential therapeutic targets. She employs advanced methodologies, including CRISPR knockout, fluorescence microscopy, and mechanobiology assays, to uncover novel insights into cell behavior under stress conditions.

Awards & Recognition 🏆

Dr. Bastianello has received the prestigious NAF2020 Young Investigator Award for her research on Ataxia-Telangiectasia and cytoskeletal stress. She has also secured multiple research fellowships at the University of Milan, highlighting her contributions to oncology and molecular biology. Her work is widely recognized in the scientific community, and she actively participates in leading international conferences.

📄 Publications

A Multiparametric Screen Uncovers FDA-Approved Small Molecules That Potentiate the Nuclear Mechano-Dysfunctions in ATR-Defective Cells 🧬🔍
👨‍🏫 Authors: Cera MR, Bastianello G, Purushothaman D, Andronache A, Ascione F, Robusto M, Fagà G, Pasi M, Meroni G, Li Q et al.
📖 Journal: Scientific Reports 🏛️
📅 Publication Date: 2024-12-28

Mechanical Stress During Confined Migration Causes Aberrant Mitoses and c-MYC Amplification 🔬⚡
👨‍🏫 Authors: Bastianello G, Kidiyoor GR, Lowndes C, Li Q, Bonnal R, Godwin J, Iannelli F, Drufuca L, Bason R, Orsenigo F et al.
📖 Journal: Proceedings of the National Academy of Sciences (PNAS) 🏛️

Germinal Center Dark Zone Harbors ATR-Dependent Determinants of T-Cell Exclusion That Are Also Identified in Aggressive Lymphoma 🏥🦠
👨‍🏫 Authors: Tripodo C, Cancila V, Morello G, Bertolazzi G, Chan ASY, Bastianello G, Paysan D, Jaynes PW, Schiavoni G, Mattei F et al.
📖 Journal: Preprint
📅 Publication Date: 2024-03-18

Cell Stretching Activates an ATM Mechano-Transduction Pathway That Remodels Cytoskeleton and Chromatin 🔗🔬
👨‍🏫 Authors: Bastianello G, Porcella G, Beznoussenko GV, Kidiyoor G, Ascione F, Li Q, Cattaneo A, Matafora V, Disanza A, Quarto M et al.
📖 Journal: Cell Reports 🏛️
📅 Publication Date: 2023-12

Mechanisms Controlling the Mechanical Properties of the Nuclei 🧪📊
👨‍🏫 Authors: Bastianello G, Foiani M
📖 Journal: Current Opinion in Cell Biology 🏛️
📅 Publication Date: 2023-10

Cancer Cell Histone Density Links Global Histone Acetylation, Mitochondrial Proteome, and Histone Acetylase Inhibitor Sensitivity 🏥🧬
👨‍🏫 Authors: Bastianello G
📖 Journal: Communications Biology 🏛️
📅 Publication Date: 2022-08-27

Prof. Giulia Bastianello’s cutting-edge research in molecular oncology, DNA damage response, and nuclear mechanics has made significant contributions to cancer biology and biomedical sciences. Her work continues to shape the future of oncology, cell mechanics, and therapeutic advancements.

Dr Giulia Bastianello | Mechanical Properties of Materials | Best Researcher Award