Dr Chih-Jung Chang | Nanomaterials | Best Researcher Award
Dr. Chih-Jung Chang is a prominent researcher in microbiology, immunology, and gut microbiota, with a research focus that spans from traditional Chinese medicine to extracellular vesicle biology. Holding a Ph.D. from the Graduate Institute of Biomedical Science at Chang Gung University, he currently serves as an Associate Research Fellow at Xiamen Chang Gung Hospital. His prolific research contributions include more than 50 peer-reviewed articles in high-impact journals, several patents, and notable international conference presentations. Dr. Chang’s work is widely recognized for its innovation in microbiome-based therapeutics, immune modulation, and metabolic disease intervention.
Dr Chih-Jung Chang, Huaqiao University, China
Profile
SCOPUS
🎓 Education
Dr. Chih-Jung Chang holds a strong multidisciplinary academic background spanning nutrition, biotechnology, and biomedical science 🎓🧬📚. He earned his Ph.D. in Microbiology and Immunology from the Graduate Institute of Biomedical Science at Chang Gung University (2010–2015) 🔬🧫. Prior to that, he completed a Master’s degree in Medical Biotechnology and Laboratory Science from the same university (2007–2009) 🧪💉. His academic journey began with a Bachelor’s degree in Nutrition from Chung Shan Medical University (2003–2007) 🥗📘. This robust educational foundation has empowered him to conduct impactful, cross-disciplinary research in immunology, microbiota, and disease modulation 🌱🧠.
🏥 Experience
Dr. Chih-Jung Chang has built an impressive research career in immunology and microbiota science 🧬🧫. He began as a Postdoctoral Fellow at the Molecular and Clinical Immunology Center, Chang Gung University (2015–2017) 🧪📚. He then advanced to Assistant Research Fellow at the Microbiota Research Center (2017–2019), where he deepened his work on host-microbe interactions 🔬🌱. Since 2019, he has been serving as an Associate Research Fellow at the Medical Research Center, Xiamen Chang Gung Hospital 🏥💡. His roles reflect a consistent focus on translational microbiome research, immunomodulation, and innovative biomedical applications 🌍💊.
🏅 Award
Dr. Chih-Jung Chang has received prestigious accolades for his outstanding academic and scientific contributions 🏅📚. He was honored with the Excellent Thesis Award by the 7th Wang Minning Foundation in Taiwan, recognizing his impactful doctoral research in microbiology and immunology 🎓🔬. Additionally, he earned the Distinguished Paper Award from the Taiwan Society for Microbiology for his innovative work in gut microbiota and immune modulation 🧫🧠. These awards reflect his excellence in scientific writing, original research, and contributions to the global microbiological community 🌍📖, strengthening his reputation as a leader in biomedical science.
🎤 Conference Presentation
Dr. Chih-Jung Chang has actively presented his groundbreaking research on gut microbiota, extracellular vesicles, and natural immunomodulators at international conferences across the USA, Australia, China, and Fiji 🌍🎤. His studies highlight the effects of Ganoderma lucidum and Antrodia cinnamomea on natural killer cells, immune signaling, and obesity modulation 🧫🦠🔥. He also explored Akkermansia muciniphila‘s role in metabolic regulation and EV-based diagnostics in allergic rhinitis and lung injury 🧬💨. From Lorne Infection & Immunity to ISEV 2024, his work bridges microbiome science with clinical innovation, earning global attention in the field of biomedical microbiology 🧠🔬🌱.
🌿 Patent
Dr. Chih-Jung Chang holds multiple U.S. patents focused on natural compound-based therapies 🌿🧪. His inventions include novel methods to extract Ganoderma lucidum and Hirsutella sinensis polysaccharides with anti-obesity, insulin-sensitizing, and liver-protective effects 💊🩺. He also pioneered microbiome-driven approaches using Parabacteroides goldsteinii to reduce body fat, improve glucose tolerance, and treat fatty liver disease 🧫⚖️🍽️. These patents reflect his innovative contributions to functional foods, microbiome-based therapeutics, and metabolic disease management 🔬🧠. His work bridges natural medicine with cutting-edge biotechnology for tackling global health challenges related to obesity, diabetes, and inflammation 🌍💡.
🔬 Research Focus
Dr. Chih-Jung Chang’s research focuses on the interplay between the gut microbiota, extracellular vesicles, and host immunity, using advanced multi-omics technologies 🧬🔬. His work explores how microbiome-derived vesicles influence diseases such as psoriasis, gestational diabetes, asthma, and inflammatory disorders 🤒🧫. By employing animal models like mice and zebrafish 🐭🐟, he investigates the anti-inflammatory, antioxidative, and immunomodulatory properties of natural compounds and microbial signals 🌿💊. Dr. Chang’s goal is to translate these findings into novel therapeutic strategies and diagnostic biomarkers for chronic diseases, contributing significantly to the field of precision microbiome medicine 🧠🩺🌍.
📚 Publications
Multi-omics Analysis of Outer Membrane Vesicles from P. goldsteinii in a Psoriasis Mouse Model
Authors: Zhaoxiang Xie, Rongqin Ke, Chih-Jung Chang, et al.
Journal: Life Sciences (2025)
Anti-inflammatory and Antioxidative Effects of Perilla frutescens-Derived Extracellular Vesicles: Insights from Zebrafish Models
Authors: Jinghong Huang, Linxin Chen, Wenhua Li, Chih-Jung Chang
Journal: Molecular Immunology (2025)
Microbiome Analysis of Serum Extracellular Vesicles in Gestational Diabetes Patients
Authors: Chih-Jung Chang, Yuci Bai, Hong Jiang, Hungchien Huang, Tien Jui Chen
Journal: Acta Diabetologica (2025)